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Science 30 October 1981:
Vol. 214. no. 4520, pp. 579 - 581
DOI: 10.1126/science.7292000
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Articles

Science, Vol 214, Issue 4520, 579-581
Copyright © 1981 by American Association for the Advancement of Science

articles

Regeneration of neurites on long-term cultures of sympathetic neurons deprived of nerve growth factor

RB Campenot

Sympathetic neurons from newborn rats, cultured for 1 month or longer in the virtual absence of nonneuronal cells, were capable of regenerating neurites after neuritotomy. Regeneration occurred even after nerve growth factor was withdrawn from the cultures, although it was much less extensive and appeared limited to a few days following neuritotomy. Even after 29 days of nerve growth factor deprivation, reintroduction of the protein prompted a resumption of neurite growth. Possible roles of both nerve growth factor-independent and -dependent components in adult nerve regeneration are discussed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Survival of adult basal forebrain cholinergic neurons after loss of target neurons.
M. Sofroniew, N. Galletly, O Isacson, and C. Svendsen (1990)
Science 247, 338-342
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