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Science 30 October 1981:
Vol. 214. no. 4520, pp. 577 - 578
DOI: 10.1126/science.7291999
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Articles

Science, Vol 214, Issue 4520, 577-578
Copyright © 1981 by American Association for the Advancement of Science

articles

Ganglioside stimulation of axonal sprouting in vitro

FJ Roisen, H Bartfeld, R Nagele, and G Yorke

Bovine brain gangliosides were applied to primary and established neuronal cultures to examine the role of gangliosides in neuronal development. Media containing gangliosides enhanced the degree of axonal elongation exhibited by sensory ganglia neurons and increased the length and number of Neuro-2a neuroblastoma cell processes. Ganglioside-supplemented media caused a twofold increase in ornithine decarboxylase activity in both culture systems. These experiments suggest that gangliosides function as acceptor molecules for growth-promoting substances in embryonic and tumor-derived neurons.


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