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Science 30 October 1981:
Vol. 214. no. 4520, pp. 573 - 575
DOI: 10.1126/science.7291998
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Articles

Science, Vol 214, Issue 4520, 573-575
Copyright © 1981 by American Association for the Advancement of Science

articles

Persistent behavior at high rates maintained by intravenous self-administration of nicotine

Goldberg SR, RD Spealman, and DM Goldberg

Squirrel monkeys pressed a level at high rates under a second-order schedule of reinforcement in which level pressing produced a brief visual stimulus that was occasionally contiguous with an intravenous injection of nicotine. The rate of lever pressing could be markedly reduced either by substituting saline for nicotine injections or by blocking the effects of nicotine with mecamylamine. The rate of level pressing could be reduced by eliminating the brief visual stimulus. These results show that nicotine can function as an effective reinforcer under a second-order schedule of drug self-administration and that an environmental stimulus associated with nicotine intake can contribute to the maintenance of persistent drug-seeking behavior.


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