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Science 30 October 1981:
Vol. 214. no. 4520, pp. 571 - 573
DOI: 10.1126/science.7291997
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Articles

Science, Vol 214, Issue 4520, 571-573
Copyright © 1981 by American Association for the Advancement of Science

articles

Cerebral cortex responds rapidly to thyroid hormones

JL Leonard, MM Kaplan, TJ Visser, JE Silva, and PR Larsen

In rats subjected to thyroidectomy there was a two- to fourfold increase in cerebral cortex iodothyronine 5'-deiodinase activity within 24 hours. This increase was prevented by thyroxine replacement. The increased cortical 5'-deiodinase in chronically hypothyroid rats was normalized within 4 hours by a single intravenous injection of triiodothyronine. These results indicate that the adult central nervous system can give a very rapid biochemical response to thyroid hormone.


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