Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 16 October 1981:
Vol. 214. no. 4518, pp. 339 - 341
DOI: 10.1126/science.7280695
Prev | Table of Contents | Next

Articles

Science, Vol 214, Issue 4518, 339-341
Copyright © 1981 by American Association for the Advancement of Science

articles

Modulation of parallel fiber excitability by postsynaptically mediated changes in extracellular potassium

RC Malenka, JD Kocsis, BR Ransom, and SG Waxman

Field potentials and extracellular potassium concentration ([K+]o) were simultaneously monitored in the molecular layer of the rat cerebellar cortex during stimulation of the parallel fibers. The synaptic field potential elicited by stimulation was reduced by several methods. Reduction of synaptic field potentials was accompanied by a marked increase in the excitability of the parallel fibers. This change in excitability was related to the degree of extracellular K+ accumulation associated with parallel fiber stimulation. These findings support the proposal that increases in [K+]o associated with activity in postsynaptic elements can modulate the excitability of presynaptic afferent fibers.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mechanisms underlying short-term modulation of transmitter release by presynaptic depolarization.
T. Hori and T. Takahashi (2009)
J. Physiol. 587, 2987-3000
   Abstract »    Full Text »    PDF »
Potassium Dynamics in the Epileptic Cortex: New Insights on an Old Topic.
F. Frohlich, M. Bazhenov, V. Iragui-Madoz, and T. J. Sejnowski (2008)
Neuroscientist 14, 422-433
   Abstract »    PDF »
Action potential fidelity during normal and epileptiform activity in paired soma-axon recordings from rat hippocampus.
J. P Meeks, X. Jiang, and S. Mennerick (2005)
J. Physiol. 566, 425-441
   Abstract »    Full Text »    PDF »
Activity-dependent excitability changes in hippocampal CA3 cell Schaffer axons.
A. F Soleng, A Baginskas, P Andersen, and M Raastad (2004)
J. Physiol. 560, 491-503
   Abstract »    Full Text »    PDF »
Unmyelinated axons in the rat hippocampus hyperpolarize and activate an H current when spike frequency exceeds 1 Hz.
A F Soleng, K Chiu, and M Raastad (2003)
J. Physiol. 552, 459-470
   Abstract »    Full Text »    PDF »
Motor Dysfunction and Altered Synaptic Transmission at the Parallel Fiber-Purkinje Cell Synapse in Mice Lacking Potassium Channels Kv3.1 and Kv3.3.
H. Matsukawa, A. M. Wolf, S. Matsushita, R. H. Joho, and T. Knopfel (2003)
J. Neurosci. 23, 7677-7684
   Abstract »    Full Text »    PDF »
Stimulus-Evoked Modulation of Sensorimotor Pyramidal Neuron EPSPs.
A. Kohn, C. Metz, M. A. Tommerdahl, and B. L. Whitsel (2002)
J Neurophysiol 88, 3331-3347
   Abstract »    Full Text »    PDF »
Contribution of Presynaptic Na+ Channel Inactivation to Paired-Pulse Synaptic Depression in Cultured Hippocampal Neurons.
Y. He, C. F. Zorumski, and S. Mennerick (2002)
J Neurophysiol 87, 925-936
   Abstract »    Full Text »    PDF »
Chloride-Cotransport Blockade Desynchronizes Neuronal Discharge in the "Epileptic" Hippocampal Slice.
D. W. Hochman and P. A. Schwartzkroin (2000)
J Neurophysiol 83, 406-417
   Abstract »    Full Text »    PDF »
Impaired Cerebellar Synaptic Plasticity and Motor Performance in Mice Lacking the mGluR4 Subtype of Metabotropic Glutamate Receptor.
R. Pekhletski, R. Gerlai, L. S. Overstreet, X.-P. Huang, N. Agopyan, N. T. Slater, W. Abramow-Newerly, J. C. Roder, and D. R. Hampson (1996)
J. Neurosci. 16, 6364-6373
   Abstract »    Full Text »    PDF »
Cellular mechanisms of epilepsy: a status report.
M. Dichter and G. Ayala (1987)
Science 237, 157-164
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)