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Science 9 October 1981:
Vol. 214. no. 4517, pp. 195 - 197
DOI: 10.1126/science.6169149
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Articles

Science, Vol 214, Issue 4517, 195-197
Copyright © 1981 by American Association for the Advancement of Science

articles

Sodium appetite in sheep induced by cerebral ventricular infusion of angiotensin: comparison with sodium deficiency

JP Coghlan, PJ Considine, DA Denton, DT Fei, LG Leksell, MJ McKinley, AF Muller, E Tarjan, RS Weisinger, and RA Bradshaw

Intraventricular administration of supraphysiological amounts of renin, nerve growth factor preparation, or angiotensin II greatly increased the consumption of water and hypertonic sodium bicarbonate solution by sheep. These effects were antagonized by intraventricular administration of drugs that prevent the formation of angiotensin II or block its receptors. The fact that these angiotensin-blocking drugs did not change the sodium intake of sodium-deficient sheep challenges the idea that central angiotensin action is involved in sodium appetite due to a deficiency.


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