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Science 9 October 1981:
Vol. 214. no. 4517, pp. 193 - 194
DOI: 10.1126/science.6269182
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Articles

Science, Vol 214, Issue 4517, 193-194
Copyright © 1981 by American Association for the Advancement of Science

articles

Hindbrain GABA receptors influence parasympathetic outflow to the stomach

DJ Williford, HS Ormsbee 3rd, W Norman, JW Harmon, TQ Garvey 3rd, JA DiMicco, and RA Gillis

Blockade of gamma-aminobutyric acid receptor function by direct microinjection of bicuculline into the nucleus ambiguous in cats produced a marked increase in gastric motility which was mediated by the vagus nerve. This effect was reversed by muscimol. These data indicate that the nucleus ambiguous may be an important brain site influencing gastric function and that the neurotransmitter controlling parasympathetic overflow from this nucleus to the stomach is gamma-aminobutyric acid.


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