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Science 2 October 1981:
Vol. 214. no. 4516, pp. 87 - 89
DOI: 10.1126/science.6169147
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Articles

Science, Vol 214, Issue 4516, 87-89
Copyright © 1981 by American Association for the Advancement of Science

articles

Species restriction of a monoclonal antibody reacting with residues 130 to 137 in encephalitogenic myelin basic protein

LR Sires, S Hruby, EC Alvord Jr, I Hellstrom, KE Hellstrom, MW Kies, R Martemspm, GE Deibler, ED Beckman, and JE Casnellie

A monoclonal antibody (immunoglobulin G1) has been produced that reacts against myelin basic protein present in or extracted from the brains of many mammals-with certain important exceptions. Because of known species differences in amino acid sequences of basic protein and of certain peptide fragments, the binding site for this particular antibody appeared likely to include residues 130 to 137. Confirmation of this hypothesis was obtained by amino acid composition of the major immunoreactive peptides produced by thermolysin digestion of human basic protein and isolated by high-performance liquid chromatography.


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