Science, Vol 214, Issue 4516, 79-82
Copyright © 1981 by American Association for the Advancement of Science
Skeletal muscle: length-dependent effects of potentiating agents
Lopez JR,
LA Wanek,
and
Taylor SR
The ability of vertebrae skeletal muscle to contract more vigorously than normal in the presence of potentiating agents depends on the initial length of a muscle cell. Other factors such as the intracellular calcium ion transient, temperature, chemical nature of the potentiating agent, and the ratio of intrinsic twitch to tetanic force influence the degree of contractile potentiation but cannot account for the length dependence. At least part of a muscle cell seems normally less than fully active during contractions not only at short lengths but also at optimal sarcomere lengths.