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Science 25 September 1981:
Vol. 213. no. 4515, pp. 1525 - 1527
DOI: 10.1126/science.7197053
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Articles

Science, Vol 213, Issue 4515, 1525-1527
Copyright © 1981 by American Association for the Advancement of Science

articles

Diurnal rhythm of cytoplasmic estrogen receptors in the rat brain in the absence of circulating estrogens

EJ Roy and MA Wilson

The concentration of cytoplasmic estrogen receptors in the brain of ovariectomized female rats varies during the light-dark cycle. There is no variation in the affinity of the receptors for estradiol, and the rhythm is not due to estrogens from nonovarian sources. Pentobarbital reverses the reduction of receptors that occurs in the dark, and melatonin injection in the light partially mimics the action of darkness in reducing receptor levels. The factors that cause this rhythm is brain estrogen receptors may be one means by which light affects reproductive function.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Estrogen Controls Branched-Chain Amino Acid Catabolism in Female Rats.
M. Obayashi, Y. Shimomura, N. Nakai, N. H. Jeoung, M. Nagasaki, T. Murakami, Y. Sato, and R. A. Harris (2004)
J. Nutr. 134, 2628-2633
   Abstract »    Full Text »    PDF »
Melatonin: a coordinating signal for mammalian reproduction?.
L Tamarkin, C. Baird, and O. Almeida (1985)
Science 227, 714-720
   Abstract »    PDF »
Decreased nocturnal plasma melatonin peak in patients with estrogen receptor positive breast cancer.
L Tamarkin, D Danforth, A Lichter, E DeMoss, M Cohen, B Chabner, and M Lippman (1982)
Science 216, 1003-1005
   Abstract »    PDF »


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