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Science 25 September 1981:
Vol. 213. no. 4515, pp. 1505 - 1508
DOI: 10.1126/science.7280670
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Articles

Science, Vol 213, Issue 4515, 1505-1508
Copyright © 1981 by American Association for the Advancement of Science

articles

Cellular aging: further evidence for the commitment theory

R Holliday, LI Huschtscha, and TB Kirkwood

A large, transient reduction in the population size of human fibroblasts in early passages significantly increases the variability of the life-spans of cultures in comparison to control cultures, as predicted by the commitment theory of cellular aging. The theory also predicts that a constant population of noncycling cells will appear in the later part of the culture life-span. This was confirmed by labeling the cells in culture with tritiated thymidine.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)