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Science 11 September 1981:
Vol. 213. no. 4513, pp. 1267 - 1269
DOI: 10.1126/science.7268435
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Articles

Science, Vol 213, Issue 4513, 1267-1269
Copyright © 1981 by American Association for the Advancement of Science

articles

Autoantibodies from vasectomized guinea pigs inhibit fertilization in vitro

TT Huang Jr, KS Tung, and R Yanagimachi

Immunoglobulin G and Fab antibodies were isolated from the serum of vasectomized guinea pigs, and the effects of the antibodies on fertilization in vitro were investigated. These antibodies had profound inhibitory effects on (i) sperm-to-sperm adhesion, (ii) the acrosome reaction, (iii) sperm-zona binding, and (iv) sperm-ovum fusion. This finding may explain certain cases of infertility after vasovasostomy in men.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Systematic Characterization of Sperm-Specific Membrane Proteins in Swine.
N. P. Haden, J. R. Hickox, C. Scott Whisnant, and D. M. Hardy (2000)
Biol Reprod 63, 1839-1847
   Abstract »    Full Text »


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