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Science 28 August 1981:
Vol. 213. no. 4511, pp. 1036 - 1037
DOI: 10.1126/science.7268408
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Articles

Science, Vol 213, Issue 4511, 1036-1037
Copyright © 1981 by American Association for the Advancement of Science

articles

Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat

GP Smith, C Jerome, BJ Cushin, R Eterno, and KJ Simansky

The site where peripherally administered cholecystokinin-8 elicits satiety was investigated by injecting rats with cholecystokinin-8 (1 to 8 micrograms per kilogram of body weight, intraperitoneally) after they had received bilateral lesions of the ventromedial hypothalamus or after they had undergone bilateral abdominal vagotomy or selective vagotomies. Abdominal vagotomy or gastric vagotomy abolished or reduced the satiety effect of cholecystokinin, but lesions of the ventromedial hypothalamus did not. These results demonstrate that peripherally administered cholecystokinin acts in the abdomen through gastric vagal fibers and not directly on the brain to produce satiety in the rat.


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