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Science 21 August 1981:
Vol. 213. no. 4510, pp. 911 - 913
DOI: 10.1126/science.7256285
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Articles

Science, Vol 213, Issue 4510, 911-913
Copyright © 1981 by American Association for the Advancement of Science

articles

Cerebroventricular propranolol elevates cerebrospinal fluid norepinephrine and lowers blood pressure

RL Tackett, JG Webb, and PJ Privitera

Ventriculocisternal administration of dl- and d-propranolol produced dose-dependent increases in cerebrospinal fluid norepinephrine and reductions in blood pressure. A highly significant correlation was found between the increase in norepinephrine and the hypotensive effect. The propranolol-induced hypotension was prevented by intracisternal phentolamine. These data indicate that the hypotensive effect of centrally administered propranolol results from a drug-induced release of norepinephrine, which stimulates central alpha receptors to lower arterial pressure.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Intracerebroventricular propranolol prevented vascular resistance increases on arousal from sleep apnea.
S. Zinkovska and D. A. Kirby (1997)
J Appl Physiol 82, 1637-1643
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Cerebrospinal Fluid 3-Methoxy-4-hydroxyphenylglycol and Norepinephrine Levels in Alcohol Withdrawal: Correlations With Clinical Signs.
R. J. Hawley, L. F. Major, E. A. Schulman, and M. Linnoila (1985)
Arch Gen Psychiatry 42, 1056-1062
   Abstract »    PDF »


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