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Science 7 August 1981:
Vol. 213. no. 4508, pp. 666 - 668
DOI: 10.1126/science.7256267
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Articles

Science, Vol 213, Issue 4508, 666-668
Copyright © 1981 by American Association for the Advancement of Science

articles

Collagen alpha B chain: increased proportion in human atherosclerosis

A Ooshima

In a study of human atherosclerotic plaques, the relative abundance of alpha chains in pepsin-solubilized collagens from 28 human aortas was estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The ratio of alpha B, a component of the alpha chain in type V collagen, to alpha 1(I) was markedly increased in the atherosclerotic plaques compared to the nonsclerotic intact media and adventitia. It is suggested that proliferating smooth muscle cells in the sclerotic lesion were transformed to synthesize a larger amount of collagen alpha B chain during the process of human atherogenesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Transcription Factor CCAAT-binding Factor CBF/NF-Y and Two Repressors Regulate the Core Promoter of the Human Pro-{alpha}3(V) Collagen Gene (COL5A3).
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J. Biol. Chem. 279, 46373-46383
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Decreased Type III and V Collagen Expression in Chorionic Villi of Hydatidiform Mole.
M. Iwahashi, Y. Muragaki, A. Ooshima, and R. Nakano (2001)
J. Clin. Endocrinol. Metab. 86, 3346-3350
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Complete Processing of Type III Collagen in Atherosclerotic Plaques.
M. K. Bode, M. Mosorin, J. Satta, L. Risteli, T. Juvonen, and J. Risteli (1999)
Arterioscler Thromb Vasc Biol 19, 1506-1511
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Human Monocyte-derived Macrophages Secrete Two Forms of Proteoglycan-Macrophage Colony-stimulating Factor That Differ in Their Ability to Bind Low Density Lipoproteins.
M. Y. Chang, K. L. Olin, C. Tsoi, T. N. Wight, and A. Chait (1998)
J. Biol. Chem. 273, 15985-15992
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Elements within the First 17 Amino Acids of Human Osteonectin Are Responsible for Binding to Type V Collagen.
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Role of N-Linked Glycosylation in Human Osteonectin.
R.-L. Xie and G. L. Long (1995)
J. Biol. Chem. 270, 23212-23217
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A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis : A Report From the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.
H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull Jr, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler (1995)
Arterioscler Thromb Vasc Biol 15, 1512-1531
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A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis : A Report From the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.
H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull Jr, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler (1995)
Circulation 92, 1355-1374
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