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Science 31 July 1981:
Vol. 213. no. 4507, pp. 559 - 561
DOI: 10.1126/science.7244654
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Articles

Science, Vol 213, Issue 4507, 559-561
Copyright © 1981 by American Association for the Advancement of Science

articles

Copper deficiency suppresses the immune response of mice

Prohaska JR and OA Lukasewycz

Mice fed a purified diet low in copper display anemia, hypoceruloplasminemia, depressed concentrations of liver copper, and elevated concentrations of liver iron. An impaired humoral-mediated immune response (decreased numbers of antibody-producing cells) is observed in mice with severe as well as marginal copper deficiency. The magnitude of this impairment is highly correlated with the degree of functional copper deficiency (hypoceruloplasminemia).


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