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Science 24 July 1981:
Vol. 213. no. 4506, pp. 455 - 456
DOI: 10.1126/science.7017932
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Articles

Science, Vol 213, Issue 4506, 455-456
Copyright © 1981 by American Association for the Advancement of Science

articles

Nalidixic acid, oxolinic acid, and novobiocin inhibit yeast glycyl- and leucyl-transfer RNA synthetases

HT Wright, KC Nurse, and DJ Goldstein

Nalidixic acid and novobiocin inhibit the aminoacylation and pyrophosphate exchange activities of glycyl- and leucyl-transfer RNA synthetases from bakers' yeast. Similar types of inhibition are observed for both enzymes, suggesting similar mechanisms. The potency of these inhibitors is comparable to that observed for their inhibition of in vivo DNA synthesis in eukaryotic cells.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)