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Science 17 July 1981:
Vol. 213. no. 4505, pp. 357 - 359
DOI: 10.1126/science.7244622
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Articles

Science, Vol 213, Issue 4505, 357-359
Copyright © 1981 by American Association for the Advancement of Science

articles

Response artifact in the measurement of neuroleptic-induced anhedonia

A Ettenberg, GF Koob, and FE Bloom

Systemic administration of the neuroleptic drug alpha-flupenthixol attenuated lever-pressing behavior in rats responding for rewarding brain stimulation. The magnitude of this attenuation was dose-dependent and resembled the effects of reward reduction and termination. However, when the operant response requirements of the same rats were changed to nose poking, identical drug treatments produced relatively little attenuation in performance. These data do not support the belief that neuroleptics produce a general state of anhedonia. Rather, the apparent suppression of reinforced behaviors depends at least in part on the kinetic requirements of the response.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Time course of alpha-flupenthixol action explains "response artifacts" of neuroleptic action on brain stimulation reward.
D. CORBETT, J. R. STELLAR, L. STINUS, A. KELLEY, and G. FOURIEZOS (1983)
Science 222, 1251-1254
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Ethanol Modulation of Opiate Receptors in Cultured Neural Cells.
C. BIELAJEW (1983)
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