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Science 17 July 1981:
Vol. 213. no. 4505, pp. 353 - 354
DOI: 10.1126/science.7244620
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Articles

Science, Vol 213, Issue 4505, 353-354
Copyright © 1981 by American Association for the Advancement of Science

articles

Tonic immobility produces hyperalgesia and antagonizes morphine analgesia

MD Mauk, RD Olson, GJ LaHoste, and GA Olson

Hyperalgesia was demonstrated during and immediately after termination of tonic immobility in the lizard Anolis carolinensis. Additionally, tonic immobility antagonized morphine-induced analgesia. In conjunction with other research, these data suggest that the response is accompanied by a reduced availability of serotonin, possibly at postsynaptic receptors of raphe neurons.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)