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Science 10 July 1981:
Vol. 213. no. 4504, pp. 216 - 218
DOI: 10.1126/science.6787704
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Articles

Science, Vol 213, Issue 4504, 216-218
Copyright © 1981 by American Association for the Advancement of Science

articles

Thyrotropin-releasing hormone improves cardiovascular function in experimental endotoxic and hemorrhagic shock

JW Holaday, RJ D'Amato, and AI Faden

Thyrotropin-releasing hormone significantly improved cardiovascular function when it was injected intravenously into conscious rats subjected to experimental endotoxic or hemorrhagic shock. Because thyrotropin-releasing hormone appears to be a "physiologic: opiate antagonist without effects on pain responsiveness, it may provide therapeutic benefits in the treatment of shock or acute hypotension.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Altered Hormonal Activity in Severely Ill Patients After Injury or Sepsis.
A. E. Baue, B. Gunther, W. Hartl, M. Ackenheil, and G. Heberer (1984)
Arch Surg 119, 1125-1132
   Abstract »    PDF »
Opiate Antagonists and Thyrotropin-Releasing Hormone: I. Potential Role in the Treatment of Shock.
A. I. Faden (1984)
JAMA 252, 1177-1180
   Abstract »    PDF »
Protirelin (TRH) A Potent Neuromodulator With Therapeutic Potential.
J. W. Holaday and E. W. Bernton (1984)
Arch Intern Med 144, 1138-1140
   Abstract »    PDF »
Diagnostic Dosages of Protirelin (TRH) Elevate BP by Noncatecholamine Mechanisms.
G. P. Zaloga, B. Chernow, R. Zajtchuk, R. Chin, T. G. Rainey, and C. R. Lake (1984)
Arch Intern Med 144, 1149-1152
   Abstract »    PDF »
Brain peptides: what, where, and why?.
D. Krieger (1983)
Science 222, 975-985
   Abstract »    PDF »
A Case of Episodic Flushing and Organic Psychosis: Reversal by Opiate Antagonists.
D. J. GOLDSTEIN and H. R. KEISER (1983)
Ann Intern Med 98, 30-34
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