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Science 26 June 1981:
Vol. 212. no. 4502, pp. 1527 - 1529
DOI: 10.1126/science.7233241
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Articles

Science, Vol 212, Issue 4502, 1527-1529
Copyright © 1981 by American Association for the Advancement of Science

articles

Physical dependence on morphine fails to develop during the hibernating state

AL Beckman, C Llados-Eckman, TL Stanton, and MW Adler

Physical dependence on morphine occurs in a typical fashion during the active state of the mammalian hibernator Citellus lateralis, but does not occur when morphine exposure is confined to the hibernating state. Morphine exposure during hibernation can produce stereotyped behavior, thus demonstrating partial responsiveness of the central nervous system to opioids during this natural state.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Opioids confer myocardial tolerance to ischemia: Interaction of delta opioid agonists and antagonists.
S. F. Bolling, V. Badhwar, C. F. Schwartz, P. R. Oeltgen, K. Kilgore, and T.-P. Su (2001)
J. Thorac. Cardiovasc. Surg. 122, 476-481
   Abstract »    Full Text »    PDF »
Gene Expression in the Brain across the Hibernation Cycle.
B. F. O'Hara, F. L. Watson, H. K. Srere, H. Kumar, S. W. Wiler, S. K. Welch, L. Bitting, H. C. Heller, and T. S. Kilduff (1999)
J. Neurosci. 19, 3781-3790
   Abstract »    Full Text »    PDF »
Using Research in Practice: Mechanisms of Drug Tolerance.
B. B. Fuller (1982)
West J Nurs Res 4, 113-118
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)