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Science 26 June 1981:
Vol. 212. no. 4502, pp. 1512 - 1514
DOI: 10.1126/science.6112796
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Articles

Science, Vol 212, Issue 4502, 1512-1514
Copyright © 1981 by American Association for the Advancement of Science

articles

Lophotoxin: a novel neuromuscular toxin from Pacific sea whips of the genus Lophogorgia

W Fenical, RK Okuda, MM Bandurraga, P Culver, and RS Jacobs

A new neuromuscular toxin, lophotoxin, has been isolated from several pacific gorgonians of the genus Lophogorgia. The structure of lophotoxin was deduced by combined spectrochemical methods, and belongs to the well-known cembrene class of diterpenoid molecules. Lophotoxin contains furanoaldehyde and alpha, beta-epoxy-gamma-lactone functional groups, in sharp contrast to the cationic ammonium functional groups of the established neurotoxins.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lophotoxin Is a Slow Binding Irreversible Inhibitor of Nicotinic Acetylcholine Receptors.
D. R. Groebe and S. N. Abramson (1995)
J. Biol. Chem. 270, 281-286
   Abstract »    Full Text »    PDF »
Biotechnology in the Marine Sciences.
R. R. Colwell (1983)
Science 222, 19-24
   Abstract »    PDF »


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