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Science 5 June 1981:
Vol. 212. no. 4499, pp. 1148 - 1151
DOI: 10.1126/science.7233208
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Articles

Science, Vol 212, Issue 4499, 1148-1151
Copyright © 1981 by American Association for the Advancement of Science

articles

Long-term potentiation in the hippocampal slice: evidence for stimulated secretion of newly synthesized proteins

C Duffy, TJ Teyler, and VE Shashoua

Long-term potentiation of the hippocampal slice preparation results in an increase in the incorporation of labeled valine into the proteins destined for secretion into the extracellular medium. Double-labeling methods established that the increased secretion of the labeled proteins was limited to the potentiated region of a slice; incorporation of labeled valine was increased in the hippocampus if potentiation was through the Schaffer collaterals and in the dentate if potentiation was through the perforant path. Controls for nonspecific stimulation showed no changes. There appears to be a link between long-term potentiation and the metabolic processes that lead to protein synthesis in the hippocampal slice system.


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