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Science 22 May 1981:
Vol. 212. no. 4497, pp. 957 - 959
DOI: 10.1126/science.6262912
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Articles

Science, Vol 212, Issue 4497, 957-959
Copyright © 1981 by American Association for the Advancement of Science

articles

Synaptic excitation may activate a calcium-dependent potassium conductance in hippocampal pyramidal cells

RA Nicoll and BE Alger

In hippocampal CAl pyramidal cells, orthodromic synaptic excitation is followed by an early hyperpolarization mediated by gamma-aminobutyric acid (GABA) and a late non-GABA-mediated hyperpolarization that has properties consistent with an increase in potassium conductance. Depolarizations produced by iontophoretically applied glutamate are followed by hyperpolarizations that have features in accordance with an increase in potassium conductance. The hyperpolarizations are independent of chloride and resistant to tetradotoxin but are blocked by a low-calcium, high-cobalt medium. Voltage clamping the glutamate depolarization does not reduce the subsequent hyperpolarization, indicating that the hyperpolarization results from a direct increase in calcium conductance produced by glutamate, rather than from activation of voltage-sensitive calcium channels. A single transmitter, possibly acting on one type of receptor and channel, may initiate both excitation and inhibition in the same postsynaptic cell.


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