Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 22 May 1981:
Vol. 212. no. 4497, pp. 923 - 924
DOI: 10.1126/science.7195067
Prev | Table of Contents | Next

Articles

Science, Vol 212, Issue 4497, 923-924
Copyright © 1981 by American Association for the Advancement of Science

articles

Tumor shedding and coagulation

HF Dvorak, SC Quay, NS Orenstein, AM Dvorak, P Hahn, AM Bitzer, and AC Carvalho

Three syngeneic carcinomas from two species shed plasma membrane vesicles when cultured in vitro or grown in the ascites tumor form in vivo. Shed vesicles carry procoagulant activity that can account for the activation of the clotting system and the fibrin deposition associated with these and many other types of malignancy in animals and man.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tumor-Derived Tissue Factor-Bearing Microparticles Are Associated With Venous Thromboembolic Events in Malignancy.
J. I. Zwicker, H. A. Liebman, D. Neuberg, R. Lacroix, K. A. Bauer, B. C. Furie, and B. Furie (2009)
Clin. Cancer Res. 15, 6830-6840
   Abstract »    Full Text »    PDF »
Cancer cell-derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo.
G. M. Thomas, L. Panicot-Dubois, R. Lacroix, F. Dignat-George, D. Lombardo, and C. Dubois (2009)
J. Exp. Med. 206, 1913-1927
   Abstract »    Full Text »    PDF »
New Insights Into Cancer-Associated Thrombosis.
T. Sousou and A. A. Khorana (2009)
Arterioscler Thromb Vasc Biol 29, 316-320
   Abstract »    Full Text »    PDF »
Trousseau's syndrome: multiple definitions and multiple mechanisms.
A. Varki (2007)
Blood 110, 1723-1729
   Abstract »    Full Text »    PDF »
Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.
J. L. Yu, L. May, V. Lhotak, S. Shahrzad, S. Shirasawa, J. I. Weitz, B. L. Coomber, N. Mackman, and J. W. Rak (2005)
Blood 105, 1734-1741
   Abstract »    Full Text »    PDF »
How Tumors Make Bad Blood Vessels and Stroma.
H. F. Dvorak (2003)
Am. J. Pathol. 162, 1747-1757
   Full Text »    PDF »
Inhibition of Metastases by Anticoagulants.
M. Hejna, M. Raderer, and C. C. Zielinski (1999)
J Natl Cancer Inst 91, 22-36
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)