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Science 15 May 1981:
Vol. 212. no. 4496, pp. 818 - 820
DOI: 10.1126/science.7013068
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Articles

Science, Vol 212, Issue 4496, 818-820
Copyright © 1981 by American Association for the Advancement of Science

articles

Hormonal requirements for growth of arterial smooth muscle cells in vitro: and endocrine approach to atherosclerosis

R Weinstein, MB Stemerman, and T Maciag

In this study the hormonal requirements for the growth of arterial smooth muscle cells in vitro were determined. A serum-free, biochemically defined medium, supplemented with the relevant hormones, permitted proliferation and propagation of normal diploid mammalian arterial smooth muscle cells. Serum-free, hormone-supplemented cultures spontaneously formed atherosclerotic plaque-like nodules. Thus atherosclerosis may be mediated by a complex endocrine system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Myointimal Hyperplasia as a Result of Balloon-Catheter Thromboembolectomy.
M. A. McGurrin, J. L. Driscoll, K. B. Seifert, S. G. Brantley, F. J. Dagher, and W. M. Blackshear Jr (1991)
Arch Surg 126, 786-788
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