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Science 1 May 1981:
Vol. 212. no. 4494, pp. 546 - 547
DOI: 10.1126/science.6259738
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Articles

Science, Vol 212, Issue 4494, 546-547
Copyright © 1981 by American Association for the Advancement of Science

articles

Mutation caused by human phagocytes

SA Weitzman and TP Stossel

Histidine-requiring mutants of Salmonella typhimurium TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.


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