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Science 1 May 1981:
Vol. 212. no. 4494, pp. 543 - 545
DOI: 10.1126/science.7010606
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Articles

Science, Vol 212, Issue 4494, 543-545
Copyright © 1981 by American Association for the Advancement of Science

articles

Changes in DNA during meiosis in a repair-deficient mutant (rad 52) of yeast

MA Resnick, JN Kasimos, JC Game, RJ Braun, and RM Roth

The kinetic patterns of DNA synthesis in wild-type (RAD+) and rad 52 mutants of yeast, which exhibit high levels of synchrony during meiosis, are comparable. However, RAD 52 mutants accumulate single-strand breaks in parental DNA during the DNA synthesis period. Thus, the product of the RAD 52 gene has a role in meiotic DNA metabolism, as well as in the repair of DNA damage during mitotic growth. The observed breaks may be unresolved recombination intermediates.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Changes in the Chromosomal DNA of Yeast during Meiosis in Repair Mutants and the Possible Role of a Deoxyribonuclease.
M.A. Resnick, T. Chow, J. Nitiss, and J. Game (1984)
Cold Spring Harb Symp Quant Biol 49, 639-649
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