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Science 24 April 1981:
Vol. 212. no. 4493, pp. 455 - 457
DOI: 10.1126/science.7010605
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Articles

Science, Vol 212, Issue 4493, 455-457
Copyright © 1981 by American Association for the Advancement of Science

articles

Suppressible four-base glycine and proline codons in yeast

TF Donahue, PJ Farabaugh, and GR Fink

Five ICR-170--induced mutations at the His4 locus in yeast are +1 G.C (G, guanine; C, cytosine) additions in DNA regions that contain multiple G.C base pairs. These mutations represents both nonsuppressible and suppressible alleles. All externally, suppressible frameshift mutations occur in glycine and proline codons to produce the four-base codons GGGU (U, uracil), GGGG, and CCCU. This implies that suppression of these four-base codons in yeast, as in bacteria, involves a four-base anticodon or its functional equivalent. Two identical four-base codons (CCCU) at widely separate regions with His4 are not suppressed equally.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Gripping Tale of Ribosomal Frameshifting: Extragenic Suppressors of Frameshift Mutations Spotlight P-Site Realignment.
J. F. Atkins and G. R. Bjork (2009)
Microbiol. Mol. Biol. Rev. 73, 178-210
   Abstract »    Full Text »    PDF »
Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon..
Y Cui, K W Hagan, S Zhang, and S W Peltz (1995)
Genes & Dev. 9, 423-436
   Abstract »    PDF »
The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon..
P Leeds, S W Peltz, A Jacobson, and M R Culbertson (1991)
Genes & Dev. 5, 2303-2314
   Abstract »    PDF »


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