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Science 17 April 1981:
Vol. 212. no. 4492, pp. 338 - 340
DOI: 10.1126/science.7209533
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Articles

Science, Vol 212, Issue 4492, 338-340
Copyright © 1981 by American Association for the Advancement of Science

articles

Alcohol-dependent liver cell necrosis in vitro: a new model

FA Schanne, AH Zucker, JL Farber, and E Rubin

In alcoholic liver injury, necrosis is involved in the progression from benign fatty liver to alcoholic hepatitis and cirrhosis. However, there is no practical model of alcohol-dependent liver cell necrosis. The calcium-dependent killing of cultured rat hepatocytes by two different membrane-active hepatotoxins, galactosamine and phalloidin, is potentiated by ethyl alcohol. This indicates that some general physical effect of alcohol on cellular membranes renders cells susceptible to otherwise nonlethal injuries. The in vitro model described in this report may thus be used to search for a general mechanism underlying alcohol-related tissue injury.


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