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Science 3 April 1981:
Vol. 212. no. 4490, pp. 63 - 65
DOI: 10.1126/science.7209520
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Articles

Science, Vol 212, Issue 4490, 63-65
Copyright © 1981 by American Association for the Advancement of Science

articles

Gene for neuraminidase activity on mouse chromosome 17 near h-2: pleiotropic effects on multiple hydrolases

JE Womack, DL Yan, and M Potier

The low activity of liver neuraminidase that is characteristic of mouse strain SM/J is inherited as a single gene on chromosome 17, near the major histocompatibility complex. This gene, neuraminidase-1 (Neu-1), is represented by the low activity allele Neu-1s in SM/J and the high activity allele Neu-1b in C57BL/6J and most other strains. Previously described variations in the posttranslational processing of acid phosphatase, alpha-mannosidase, arylsulfatase-B, and alpha-glucosidase are attributed to pleiotropic effects of this gene.


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