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Science 3 April 1981:
Vol. 212. no. 4490, pp. 58 - 60
DOI: 10.1126/science.7209517
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Articles
Science, Vol 212, Issue 4490, 58-60
Copyright © 1981 by American Association for the Advancement of Science
Nitrogen-13-labeled nitrite and nitrate: distribution and metabolism after intratracheal administration
NJ Parks,
KJ Krohn,
CA Mathis,
JH Chasko,
KR Geiger,
ME Gregor,
and
NF Peek
Radioactive nitrogen-13 from nitrite (NO2-) or nitrate (NO3-) administered intratracheally or intravenously without added carrier to mice or rabbits was distributed evenly throughout most organs and tissues regardless of the entry route or the anion administered. Nitrogen-13 from both anions was distributed uniformly between plasma and blood cells. We found rapid in vivo oxidation of NO2- to NO3- at concentrations of 2 to 3 nanomoles per liter in blood. Over 50 percent oxidation within 10 minutes accounted for the similar nitrogen-13 distributions from both parent ions. The oxidation rates were animal species-dependent. No reduction of 13NO3- to 13NO2- was observed. A mechanistic hypothesis invoking oxidation of 13NO2- by a catalase-hydrogen peroxide complex accounts for the results. These results imply a concentration dependence for the in vivo fate of NO2- or nitrogen dioxide.
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