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Science 3 April 1981:
Vol. 212. no. 4490, pp. 53 - 55
DOI: 10.1126/science.6163212
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Articles

Science, Vol 212, Issue 4490, 53-55
Copyright © 1981 by American Association for the Advancement of Science

articles

Specific antigen in serum of patients with colon carcinoma

H Koprowski, M Herlyn, Z Steplewski, and HF Sears

The binding of monoclonal antibody specific for colon carcinoma was inhibited by serum from patients with adenocarcinoma of the colon but not by serum from patients with other bowel diseases or from healthy volunteers. Of other malignancies studied, serum from two patients with gastric carcinoma and two patients with pancreatic carcinoma also inhibited the specific binding of monoclonal antibody. The levels of carcinoembryonic antigen in these serum samples were not correlated with their levels of binding inhibition. Such monoclonal antibodies may prove useful for the detection of colorectal carcinoma.


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