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Science 3 April 1981:
Vol. 212. no. 4490, pp. 49 - 51
DOI: 10.1126/science.7209515
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Articles

Science, Vol 212, Issue 4490, 49-51
Copyright © 1981 by American Association for the Advancement of Science

articles

Vasopressin analogs that antagonize antidiuretic responses by rats to the antidiuretic hormone

WH Sawyer, PK Pang, J Seto, M McEnroe, B Lammek, and M Manning

Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats. They also cause a diuresis resembling that of diabetes insipidus when given intraperitoneally to conscious rats. Such antagonists may prove to be useful both pharmacologically and therapeutically.


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