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Science 27 March 1981:
Vol. 211. no. 4489, pp. 1427 - 1429
DOI: 10.1126/science.6781067
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Articles

Science, Vol 211, Issue 4489, 1427-1429
Copyright © 1981 by American Association for the Advancement of Science

articles

Detection of a milk factor that facilitates folate uptake by intestinal cells

N Colman, N Hettiarachchy, and V Herbert

Folate binding proteins in milk were tested for their effect on folate absorption. The uptake of bound folate by isolated mucosal cells from the rat small intestine was twice that of free folate and differed from it in being more effective with progression down the small intestine, in not being affected by glucose or Dilantin, in having a higher pH optimum, and in being affected by calcium concentration. This milk factor may enhance folate absorption in infants, whose risk of folate deficiency is high.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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G. Hay, C. Johnston, A. Whitelaw, K. Trygg, and H. Refsum (2008)
Am. J. Clinical Nutrition 88, 105-114
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Effect of cow milk on food folate bioavailability in young women.
M. F. Picciano, S. G West, A. L Ruch, P. M Kris-Etherton, G. Zhao, K. E Johnston, D. H Maddox, V. K Fishell, D. B Dirienzo, and T. Tamura (2004)
Am. J. Clinical Nutrition 80, 1565-1569
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The Binding of Folic Acid and 5-Methyltetrahydrofolate to Folate-Binding Proteins during Gastric Passage Differs in a Dynamic In Vitro Gastrointestinal Model.
M. Verwei, K. Arkbage, H. Mocking, R. Havenaar, and J. Groten (2004)
J. Nutr. 134, 31-37
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Bioaccessibility of Folic Acid and (6S)-5-Methyltetrahydrofolate Decreases after the Addition of Folate-Binding Protein to Yogurt as Studied in a Dynamic In Vitro Gastrointestinal Model,2.
K. Arkbage, M. Verwei, R. Havenaar, and C. Witthoft (2003)
J. Nutr. 133, 3678-3683
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Folic Acid and 5-Methyltetrahydrofolate in Fortified Milk Are Bioaccessible as Determined in a Dynamic In Vitro Gastrointestinal Model.
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J. Nutr. 133, 2377-2383
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Nutritional and physiologic significance of human milk proteins.
B. Lonnerdal (2003)
Am. J. Clinical Nutrition 77 , 1537S-1543S
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Dietary Interactions Influence the Effects of Bovine Folate-Binding Protein on the Bioavailability of Tetrahydrofolates in Rats.
M. L. Jones, T. Treloar, and P. F. Nixon (2003)
J. Nutr. 133, 489-495
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