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Science 20 March 1981:
Vol. 211. no. 4488, pp. 1272 - 1278
DOI: 10.1126/science.7010601
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Articles

Science, Vol 211, Issue 4488, 1272-1278
Copyright © 1981 by American Association for the Advancement of Science

articles

Mechanisms of gonadal differentiation

FP Haseltine and S Ohno

Sex differentiation is the result of the translation of genetic sex into gonadal sex. Without recognizable masculinizing signals the embryonic gonad will undergo ovarian differentiation. The main determinant of gonadal differentiation appears to be the presence or absence of a cell surface antigen, called H-Y antigen. The regulation of H-Y antigen expression is complex and involves the interaction between regulatory sites on the Y chromosome, the X chromosome, and possibly the autosomes.


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