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Science 13 March 1981: Vol. 211. no. 4487, pp. 1179 - 1180 DOI: 10.1126/science.6258228
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Articles
Science, Vol 211, Issue 4487, 1179-1180
Copyright © 1981 by American Association for the Advancement of Science
Growth factors modulate gonadotropin receptor induction in granulosa cell cultures
JS Mondschein
and
DW Schomberg
Epidermal growth factor and fibroblast growth factor inhibited follicle-stimulating hormone-dependent induction of luteinizing hormone receptor in cultured ovarian granulosa cells of the rat. In contrast, platelet-derived growth factor potentiated the induction of luteinizing hormone receptor by follicle-stimulating hormone. These results indicate that growth factors, well known for their effects on mitosis and DNA synthesis in cultured mammalian cells, are also able to modulate hormone-dependent differentiation in an endocrine target cell.
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