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Science 6 March 1981:
Vol. 211. no. 4486, pp. 1046 - 1048
DOI: 10.1126/science.6110243

Articles

Science, Vol 211, Issue 4486, 1046-1048
Copyright © 1981 by American Association for the Advancement of Science


articles

Korean hemorrhagic fever: propagation of the etiologic agent in a cell line of human origin

GR French, RS Foulke, OA Brand, GA Eddy, HW Lee, and PW Lee

The etiologic agent of Korean hemorrhagic fever has been propagated in a human cultured cell line derived from a carcinoma of the lung. The cells, described as type II, alveolar epithelial, support replication of the agent and successive passages. Antigen of the Korean hemorrhagic fever agent is readily detected in infected cells by means of direct or indirect fluorescent antibody techniques. Previous attempts to propagate this agent in vitro had been unsuccessful.


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