Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 13 February 1981:
Vol. 211. no. 4483, pp. 725 - 727
DOI: 10.1126/science.6256859
Prev | Table of Contents | Next

Articles

Science, Vol 211, Issue 4483, 725-727
Copyright © 1981 by American Association for the Advancement of Science

articles

Interaction between purine and benzodiazepine: Inosine reverses diazepam-induced stimulation of mouse exploratory behavior

JN Crawley, PJ Marangos, SM Paul, P Skolnick, and FK Goodwin

Inosine, 2-deoxyinosine, and 2-deoxyguanosine completely reversed the increase in exploratory activity elicited in mice by diazepam. The inhibition of exploratory behavior by purines occurred at doses that when given alone have no effect on exploratory behavior. 7-Methylinosine, which does not bind to the brain benzodiazepine binding site in vitro, had no effect on the diazepam-induced increase in exploratory behavior. Behavioral effects produced by various combinations of inosine and diazepam indicate that the interaction between purine and benzodiazepine is antagonistic and support the hypothesis that the naturally occurring purines function in anxiety-related behaviors that respond to benzodiazepine treatment.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Purinergic regulation of food intake.
A. Levine and J. Morley (1982)
Science 217, 77-79
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)