Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 13 February 1981:
Vol. 211. no. 4483, pp. 719 - 721
DOI: 10.1126/science.7455708
Prev | Table of Contents | Next

Articles

Science, Vol 211, Issue 4483, 719-721
Copyright © 1981 by American Association for the Advancement of Science

articles

Exposure of newborn rats to pharmacologically active compounds may permanently alter carcinogen metabolism

RA Faris and TC Campbell

Administration of phenobarbital to mother rats during early lactation causes long-term, perhaps permanent, alteration of hepatic microsomal mixed-function oxidase activity and aflatoxin B1 adduct formation in the adult male offspring. These findings suggest that perinatal exposure to pharmacologically active compounds may be a determinant of cancer risk.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Modulation of Hepatic CYP2A1, CYP2C11, and CYP3A9 Expression in Adult Rats by Neonatal Administration of Tamoxifen.
M. Kawai, S. M. Bandiera, T. K. H. Chang, F. M. Poulet, P. M. Vancutsem, and G. D. Bellward (1999)
Drug Metab. Dispos. 27, 1392-1398
   Abstract »    Full Text »
Cerebral Lateralization: Biological Mechanisms, Associations, and Pathology: III. A Hypothesis and a Program for Research.
N. Geschwind and A. M. Galaburda (1985)
Arch Neurol 42, 634-654
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)