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Science 30 January 1981:
Vol. 211. no. 4481, pp. 493 - 494
DOI: 10.1126/science.7455690
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Articles

Science, Vol 211, Issue 4481, 493-494
Copyright © 1981 by American Association for the Advancement of Science

articles

Opiate antagonist improves neurologic recovery after spinal injury

AI Faden, TP Jacobs, and JW Holaday

The opiate antagonist naloxone has been used to treat cats subjected to cervical spinal trauma. In contrast to saline-treated controls, naloxone treatment significantly improved the hypotension observed after cervical spinal injury. More critically, naloxone therapy significantly improved neurologic recovery. These findings implicate endorphins in the pathophysiology of spinal cord injury and indicate that narcotic antagonists may have a therapeutic role in this condition.


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