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Science 23 January 1981:
Vol. 211. no. 4480, pp. 398 - 400
DOI: 10.1126/science.7221546
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Articles

Science, Vol 211, Issue 4480, 398-400
Copyright © 1981 by American Association for the Advancement of Science

articles

A metronidazole metabolite in human urine and its risk

RL Kock, BB Beaulieu Jr, EJ Chrystal, and P Goldman

Metronidazole is a drug used for the treatment of trichomonal vaginitis, amebiasis, giardiasis, and certain anaerobic bacterial infections in humans. Acetamide and N-(2-hydroxyethyl)oxamic acid are metabolites of metronidazole in the rat, and we find small amounts of both metabolites in the urine of human patients taking the drug. Although acetamide is carcinogenic for rats, we do not believe that our finding further defines metronidazole's risk for humans. That risk can only be estimated from surveillance of people previously exposed to the drug.


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