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Science 23 January 1981:
Vol. 211. no. 4480, pp. 396 - 398
DOI: 10.1126/science.7194505
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Articles

Science, Vol 211, Issue 4480, 396-398
Copyright © 1981 by American Association for the Advancement of Science

articles

Mouse oocytes transcribe injected Xenopus 5S RNA gene

RL Brinster, HY Chen, and ME Trumbauer

Transcripts produced after injection of the Xenopus 5S RNA gene into oocyte germinal vesicles of mice migrate electrophoretically with the 5S RNA marker, an indication that the gene is transcribed and processed with considerable accuracy. Approximately two 5S RNA molecules are transcribed per gene per hour. This system may be useful in studying DNA processing and gene regulation by the mammalian ovum and might be modified to allow permanent incorporation of specific genes into mice.


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The need for enhancers is acquired upon formation of a diploid nucleus during early mouse development..
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