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Science 9 January 1981:
Vol. 211. no. 4478, pp. 182 - 185
DOI: 10.1126/science.6255566
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Articles

Science, Vol 211, Issue 4478, 182-185
Copyright © 1981 by American Association for the Advancement of Science

articles

2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research

MM Slaughter and RF Miller

Information processing in the vertebrate retina occurs in two separate channels known as ON and OFF channels. When intracellular electrophysiological recordings were obtained from the perfused retina-eyecup preparation of the mud-puppy (Necturus maculosus), the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge. 2-Amino-4-phosphonobutyric acid blocks the light response of the ON bipolar cell by mimicking the endogenous photoreceptor transmitter.


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