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Science 9 January 1981:
Vol. 211. no. 4478, pp. 171 - 176
DOI: 10.1126/science.7444458
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Articles

Science, Vol 211, Issue 4478, 171-176
Copyright © 1981 by American Association for the Advancement of Science

articles

Left-handed double helical DNA: variations in the backbone conformation

AJ Wang, GJ Quigley, FJ Kolpak, G van der Marel, JH van Boom, and A Rich

Four different crystals of d(CpGpCpGpCpG) have been solved by x-ray diffraction analysis and all form similar left-handed double helical Z-DNA molecules in the crystal lattice. Two different conformations are observed for the phosphates in the GpC sequences, as the phosphates are found either facing the helical groove or rotated away from it. The latter conformation is often found when hydrated magnesium ions are complexed to a phosphate oxygen atom. These different conformations may be used when right-handed B-DNA joins left-handed Z-DNA. Atomic coordinates and torsion angles are presented for both types of Z-DNA.


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Cobalt hexammine induced tautomeric shift in Z-DNA: the structure of d(CGCGCA).d(TGCGCG) in two crystal forms.
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High salt solution structure of a left-handed RNA double helix.
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Unusual DNA duplex and hairpin motifs.
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Solution Structure of a Cisplatin-Induced DNA Interstrand Cross-Link.
H. Huang, L. Zhu, B. R. Reid, G. P. Drobny, and P. B. Hopkins (1995)
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Z-DNA forms without an alternating purine-pyrimidine sequence in solution.
J Feigon, A. Wang, G. van der Marel, J. van Boom, and A Rich (1985)
Science 230, 82-84
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Helix Geometry and Hydration in A-DNA, B-DNA, and Z-DNA.
R.E. Dickerson, H.R. Drew, B.N. Conner, M.L. Kopka, and P.E. Pjura (1983)
Cold Spring Harb Symp Quant Biol 47, 13-24
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Right-handed and Left-handed Double-helical DNA: Structural Studies.
A.H.-J. Wang, S. Fujii, J.H. van Boom, and A. Rich (1983)
Cold Spring Harb Symp Quant Biol 47, 33-44
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Left-handed DNA Duplexes.
V. Sasisekharan (1983)
Cold Spring Harb Symp Quant Biol 47, 45-52
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DNA Formed by Reassociation of Complementary Single-stranded Circles from Natural DNA Is Shown to Contain Left- and Right-handed Double Helices.
S. Brahms, J. Vergne, J.G. Brahms, E. Di Capua, P. Bucher, and T. Koller (1983)
Cold Spring Harb Symp Quant Biol 47, 119-124
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Transitions Induced by Metal Complexes among Several Forms of DNA.
G.L. Eichhorn, Y.A. Shin, and J.J. Butzow (1983)
Cold Spring Harb Symp Quant Biol 47, 125-127
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Electron Microscopy of "Z-DNA".
H. Castleman and B.F. Erlanger (1983)
Cold Spring Harb Symp Quant Biol 47, 133-142
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Generation of Left-handed Z-DNA in Solution and Visualization in Polytene Chromosomes by Immunofluorescence.
T.M. Jovin, J.H. van de Sande, D.A. Zarling, D.J. Arndt-Jovin, F. Eckstein, H.H. Fuldner, C. Greider, I. Grieger, E. Hamori, B. Kalisch, et al. (1983)
Cold Spring Harb Symp Quant Biol 47, 143-154
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Theoretical Probes of DNA Conformation Examining the B->Z Conformational Transition.
W.K. Olson, A.R. Srinivasan, N.L. Marky, and V.N. Balaji (1983)
Cold Spring Harb Symp Quant Biol 47, 229-241
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Nucleosome-core Assembly on B and Z Forms of Poly[d(G-m5C)].
F.D. Miller, J.B. Rattner, and J.H. van de Sande (1983)
Cold Spring Harb Symp Quant Biol 47, 571-575
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Sites of Divergence in the Sequence of a Complex Satellite DNA and Several Cloned Variants.
D.M. Skiner, V. Bonnewell, and R.F. Fowler (1983)
Cold Spring Harb Symp Quant Biol 47, 1151-1157
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New chemistry of an old molecule: cis-[Pt(NH3)2Cl2].
S. Lippard (1982)
Science 218, 1075-1082
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The anatomy of A-, B-, and Z-DNA.
R. Dickerson, H. Drew, B. Conner, R. Wing, A. Fratini, and M. Kopka (1982)
Science 216, 475-485
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