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Science 2 January 1981:
Vol. 211. no. 4477, pp. 59 - 61
DOI: 10.1126/science.6255562
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Articles

Science, Vol 211, Issue 4477, 59-61
Copyright © 1981 by American Association for the Advancement of Science

articles

Effect of adenosine 3',5'-monophosphate on neuronal pacemaker activity: a voltage clamp analysis

SN Treistman

Bursting pacemaker activity in nerve cells can be modified for long periods by synaptic input of short duration. There is evidence that cyclic nucleotides may play a role in these modifications. The predominant effect of elevated levels of adenosine 3',5'-monophosphate in Aplysia neurons was an increased slope conductance to hyperpolarizing pulses, evident in voltage clamp records. A similar increase in slope conductance was seen as one component of maximum strength synaptic stimulation, which is consistent with the idea that cyclic nucleotides are important in the expression of synaptic alteration of bursting pacemaker activity.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)