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Science 12 December 1980:
Vol. 210. no. 4475, pp. 1247 - 1249
DOI: 10.1126/science.6254152
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Articles

Science, Vol 210, Issue 4475, 1247-1249
Copyright © 1980 by American Association for the Advancement of Science

articles

Evidence for homologous actions of pro-opiocortin products

JM Walker, H Akil, and SJ Watson

alpha-Melanocyte-stimulating hormone (alpha-MSH), a modified fragment of adrenocorticotropic hormone, derives from the same biosynthetic route as beta-endorphin and is stored by the same arcuate neurons. Microinjection of alpha-melanocyte-stimulating hormone and several related peptides into the periaqueductal gray matter significantly reduced responsiveness to pain and had a behavioral profile similar to that produced by beta-endorphin.


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The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans.
J. S. Mogil, S. G. Wilson, E. J. Chesler, A. L. Rankin, K. V. S. Nemmani, W. R. Lariviere, M. K. Groce, M. R. Wallace, L. Kaplan, R. Staud, et al. (2003)
PNAS 100, 4867-4872
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Normalizing effect of an adrenocorticotropic hormone (4-9) analog ORG 2766 on disturbed social behavior in rats.
R. Niesink and J. van Ree (1983)
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The carboxy terminus of the precursor to vasopressin and neurophysin: immunocytochemistry in rat brain.
S. Watson, N. Seidah, and M Chretien (1982)
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