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Science 5 December 1980:
Vol. 210. no. 4474, pp. 1143 - 1145
DOI: 10.1126/science.7444444
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Articles

Science, Vol 210, Issue 4474, 1143-1145
Copyright © 1980 by American Association for the Advancement of Science

articles

Electrophysiological correlates of ethanol-induced sedation in differentially sensitive lines of mice

S Sorensen, M Palmer, T Dunwiddie, and B Hoffer

Acute electrophysiological effects of ethanol were studied in two lines of mice that differ markedly in their response to the soporific effects of systemic alcohol administration. Cerebellar Purkinje neurons from the genetic line that had long sleep times were one to two orders of magnitude more sensitive to the depressant effects of locally administered ethanol than those from the line that had short sleep times. The data suggest that there are genetically determined specificities in the acute effects of ethanol on central neurons and that such specificities might be used to determine which regions of the cerebellum participate in differences in behavioral responses to this substance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Alcohol Potently Modulates Climbing Fiber->Purkinje Neuron Synapses: Role of Metabotropic Glutamate Receptors.
M. Carta, M. Mameli, and C. F. Valenzuela (2006)
J. Neurosci. 26, 1906-1912
   Abstract »    Full Text »    PDF »
Adaptation of gamma -Aminobutyric Acid Type A Receptors to Alcohol Exposure: Studies with Stably Transfected Cells.
R. A. Harris, C. F. Valenzuela, S. Brozowski, L. Chuang, K. Hadingham, and P. J. Whiting (1998)
J. Pharmacol. Exp. Ther. 284, 180-188
   Abstract »    Full Text »
Differential Development and Characterization of Rapid Acute Neuronal Tolerance to the Depressant Effects of Ethanol on Cerebellar Purkinje Neurons of Low-alcohol-sensitive and High-alcohol-sensitive Rats.
B. J. Pearson, D. P. Donatelli, R. K. Freund, and M. R. Palmer (1997)
J. Pharmacol. Exp. Ther. 280, 739-746
   Abstract »    Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)