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Science 7 November 1980:
Vol. 210. no. 4470, pp. 661 - 663
DOI: 10.1126/science.6159685
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Articles

Science, Vol 210, Issue 4470, 661-663
Copyright © 1980 by American Association for the Advancement of Science

articles

Reorganization of the axon membrane in demyelinated peripheral nerve fibers: morphological evidence

RE Foster, CC Whalen, and SG Waxman

Cytochemical staining of demyelinated peripheral axons revealed two types of axon membrane organization, one of which suggests that the demyelinated axolemma acquires a high density of sodium channels. Ferric ion-ferrocyanide stain was confined to a restricted region of axon membrane at the beginning of a demyelinated segment or was distributed throughout the demyelinated segment of axon. The latter pattern represents one possible morphological correlate of continuous conduction through a demyelinated segment and suggests a reorganization of the axolemma after demyelination.


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