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Science 7 November 1980:
Vol. 210. no. 4470, pp. 642 - 644
DOI: 10.1126/science.7433990
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Articles

Science, Vol 210, Issue 4470, 642-644
Copyright © 1980 by American Association for the Advancement of Science

articles

Oral contraceptives, lanosterol, and platelet hyperactivity in rat

M Ciavatti, E Dumont, C Benoit, and S Renaud

Lanosterol, a cholesterol precursor that increases considerably in the platelets of rats treated with oral contraceptives, was incubated with either platelet-rich plasma or washed platelet suspension. After 2 minutes there was a remarkable dose-related increase in platelet activity. This platelet hyperactivity was measured by clotting time and platelet aggregation could not be reproduced by cholesterol or ethinylestradiol.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)